Drug class

Hypercalcemia Agents

Hypercalcemia agents are a functional therapeutic group of pharmacologic therapies indicated to reduce pathologically elevated serum calcium levels. Read more about Hypercalcemia Agents

64 drugs in this class 39 manufacturers

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Drugs in Hypercalcemia Agents

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About Hypercalcemia Agents.

Hypercalcemia agents are a functional therapeutic group of pharmacologic therapies indicated to reduce pathologically elevated serum calcium levels.

These agents primarily work by inhibiting osteoclast-mediated bone resorption, increasing renal calcium excretion, or modulating parathyroid hormone secretion via calcium-sensing receptor activation.

Key drug classes utilized for this indication include intravenous bisphosphonates, the monoclonal RANK ligand inhibitor denosumab, calcitonin, and calcimimetics.

They are predominantly employed in the clinical management of hypercalcemia of malignancy, primary and secondary hyperparathyroidism, and severe parathyroid carcinoma.