Immunosuppressants - Calcineurin and mTOR Inhibitors

The phrase "Immunosuppressants - Calcineurin and mTOR Inhibitors" represents an administrative grouping of two distinct pharmacologic classes—calcineurin inhibitors (such as tacrolimus and cyclosporine) and mechanistic target of rapamycin (mTOR) inhibitors (such as sirolimus and everolimus) Both drug categories function by disrupting intracellular signaling essential for T-lymphocyte activation and proliferation, with calcineurin inhibitors blocking cytokine transcription such as interleukin-2, ...

The phrase "Immunosuppressants - Calcineurin and mTOR Inhibitors" represents an administrative grouping of two distinct pharmacologic classes—calcineurin inhibitors (such as tacrolimus and cyclosporine) and mechanistic target of rapamycin (mTOR) inhibitors (such as sirolimus and everolimus)

Both drug categories function by disrupting intracellular signaling essential for T-lymphocyte activation and proliferation, with calcineurin inhibitors blocking cytokine transcription such as interleukin-2, and mTOR inhibitors blocking downstream cell-cycle progression

Clinically, these agents are primarily used to prevent allograft rejection in solid organ transplantation, as well as to treat graft-versus-host disease and select severe autoimmune or inflammatory disorders