Drug class

Lithium

While "lithium" commonly refers to the active monovalent cation ingredient rather than a standalone therapeutic class, the Food and Drug Administration categorizes it under the established pharmacologic class of mood stabilizers. Read more about Lithium

34 drugs in this class 25 manufacturers

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Drugs in Lithium

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About Lithium.

While "lithium" commonly refers to the active monovalent cation ingredient rather than a standalone therapeutic class, the Food and Drug Administration categorizes it under the established pharmacologic class of mood stabilizers.

In clinical therapeutics, lithium salts—primarily lithium carbonate and lithium citrate—exert psychotropic effects by modulating central neurotransmission, inhibiting inositol monophosphatase and glycogen synthase kinase-3, and altering intracellular signaling cascades.

The primary indications are the management of acute manic and mixed episodes and the long-term maintenance treatment of bipolar disorder to prevent relapse, as well as adjunctive therapy in treatment-resistant major depressive disorder.

Due to a narrow therapeutic index, its use requires systematic therapeutic drug monitoring to prevent acute and chronic toxicity.