Drug class

Macrolide Immunosuppressants - Topical

Topical macrolide immunosuppressants—more widely categorized in clinical practice as topical calcineurin inhibitors—are a class of nonsteroidal immunomodulating agents that include tacrolimus and pimecrolimus. Read more about Macrolide Immunosuppressants - Topical

19 drugs in this class 9 manufacturers

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Drugs in Macrolide Immunosuppressants - Topical

Showing 1–9 of 19 drugs

TACROLIMUS

MACROLIDE IMMUNOSUPPRESSANTS - TOPICAL · ATOPIC DERMATITIS ·+1
E Fougera

PIMECROLIMUS

MACROLIDE IMMUNOSUPPRESSANTS - TOPICAL · ATOPIC DERMATITIS ·+1
OCEANSIDE PHARM

PIMECROLIMUS

MACROLIDE IMMUNOSUPPRESSANTS - TOPICAL · ATOPIC DERMATITIS ·+1
Actavis Pharma

PIMECROLIMUS

MACROLIDE IMMUNOSUPPRESSANTS - TOPICAL · ATOPIC DERMATITIS ·+1
GLENMARK PHARMA
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About Macrolide Immunosuppressants - Topical.

Topical macrolide immunosuppressants—more widely categorized in clinical practice as topical calcineurin inhibitors—are a class of nonsteroidal immunomodulating agents that include tacrolimus and pimecrolimus.

Derived structurally from macrolide antibiotics, these agents bind to the intracellular immunophilin FKBP-12 to inhibit calcineurin phosphatase activity, thereby preventing T-lymphocyte activation and suppressing the transcription of proinflammatory cytokines.

They serve primarily as second-line, steroid-sparing topical treatments for inflammatory skin conditions, predominantly atopic dermatitis (eczema), offering an alternative that avoids corticosteroid-induced cutaneous atrophy.