Drug class

Mineralocorticoids

Mineralocorticoids are a class of systemic corticosteroid hormones that play an essential role in regulating extracellular fluid volume, blood pressure, and electrolyte homeostasis. Read more about Mineralocorticoids

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Drugs in Mineralocorticoids

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About Mineralocorticoids.

Mineralocorticoids are a class of systemic corticosteroid hormones that play an essential role in regulating extracellular fluid volume, blood pressure, and electrolyte homeostasis.

They act primarily by binding to mineralocorticoid receptors in the distal renal tubules and collecting ducts, promoting sodium and water reabsorption while facilitating the excretion of potassium and hydrogen ions.

In clinical practice, synthetic mineralocorticoids such as fludrocortisone are predominantly indicated as replacement therapy for primary and secondary adrenocortical insufficiency, including Addison disease, and to manage salt-losing forms of congenital adrenal hyperplasia.

They are also utilized therapeutically to support intravascular volume in severe orthostatic hypotension.