ALKERAN (melphalan HCl)
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
APOPHARMA USA I
Drug class
Nitrogen Mustard Derivatives
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines. Read more about Nitrogen Mustard Derivatives
62 drugs in this class 45 manufacturers
Drugs in Nitrogen Mustard Derivatives
ALKERAN (melphalan)
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA ·+1
APOPHARMA USA I
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
Baxter Healthcare Company
IFEX (ifosfamide)
NITROGEN MUSTARD DERIVATIVES · TESTICULAR GERM CELL TUMOR
Baxter Healthcare Company
MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
MYLAN INSTITUTI
IFOSFAMIDE
NITROGEN MUSTARD DERIVATIVES · TESTICULAR GERM CELL TUMOR
Baxter Healthcare Company
IFEX (ifosfamide)
NITROGEN MUSTARD DERIVATIVES · TESTICULAR GERM CELL TUMOR
Baxter Healthcare Company
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
Baxter Healthcare Company
CYCLOPHOSPHAMIDE
NITROGEN MUSTARD DERIVATIVES · RETINOBLASTOMA ·+17
SANDOZ
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Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines.
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells.
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders.
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drugbank.com
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines
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nih.gov
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells Clinically represented by agents such ...
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uni-regensburg.de
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders
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