Precocious Puberty Agents

Precocious puberty agents refer to a therapeutic category of medications primarily consisting of gonadotropin-releasing hormone agonists, such as leuprolide, histrelin, and triptorelin

Precocious puberty agents refer to a therapeutic category of medications primarily consisting of gonadotropin-releasing hormone agonists, such as leuprolide, histrelin, and triptorelin These agents work by continuously stimulating pituitary GnRH receptors, which paradoxically leads to receptor desensitization and down-regulation, thereby suppressing luteinizing hormone, follicle-stimulating hormone, and downstream gonadal sex steroids to prepubertal levels They are indicated for the management o...

These agents work by continuously stimulating pituitary GnRH receptors, which paradoxically leads to receptor desensitization and down-regulation, thereby suppressing luteinizing hormone, follicle-stimulating hormone, and downstream gonadal sex steroids to prepubertal levels

They are indicated for the management of central precocious puberty, where they arrest accelerated somatic development and prevent premature epiphyseal plate fusion to preserve adult stature

In peripheral precocious puberty, adjunctive therapies such as aromatase inhibitors or androgen receptor blockers may be utilized depending on the underlying endocrine etiology

In peripheral precocious puberty, adjunctive therapies such as aromatase inhibitors or androgen receptor blockers may be utilized depending on the underlying endocrine etiology