Drug class

Quinolones

Quinolones are a class of synthetic broad-spectrum antibacterial agents that include classic agents like nalidixic acid and modern fluorinated derivatives known as fluoroquinolones. Read more about Quinolones

93 drugs in this class 54 manufacturers

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Drugs in Quinolones

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About Quinolones.

Quinolones are a class of synthetic broad-spectrum antibacterial agents that include classic agents like nalidixic acid and modern fluorinated derivatives known as fluoroquinolones.

They exert bactericidal activity by inhibiting essential bacterial type II topoisomerases—specifically DNA gyrase and topoisomerase IV—which disrupts DNA replication, transcription, and repair, ultimately leading to bacterial chromosome fragmentation and cell death.

Clinically, members of this class are utilized to treat various moderate to severe bacterial infections, including complicated urinary tract infections, pyelonephritis, respiratory tract infections such as community-acquired pneumonia, gastrointestinal infections, and intra-abdominal or skin infections.

Because of notable safety concerns, including musculoskeletal and neurological toxicities, systemic use is often reserved for circumstances where alternative antimicrobial options are ineffective or inappropriate.