Rectal Local Anesthetics

Rectal local anesthetics are a route-specific functional class of topical anesthetic formulations administered to the perineal, perianal, or lower rectal mucosa

Rectal local anesthetics are a route-specific functional class of topical anesthetic formulations administered to the perineal, perianal, or lower rectal mucosa These agents, which commonly include lidocaine, pramoxine, and benzocaine, reversibly block voltage-gated sodium channels in sensory nerve fibers, thereby inhibiting action potential generation and transmission to numb local sensory receptors

Clinically, they serve as symptomatic therapies to provide temporary relief of pain, pruritus, burning, and soreness associated with anorectal disorders, most notably internal and external hemorrhoids, anal fissures, and perianal excoriation

Clinically, they serve as symptomatic therapies to provide temporary relief of pain, pruritus, burning, and soreness associated with anorectal disorders, most notably internal and external hemorrhoids, anal fissures, and perianal excoriation