Selective Retinoid X Receptor Agonists

Selective retinoid X receptor agonists, commonly referred to as rexinoids, are a specialized antineoplastic subclass of synthetic retinoids designed to selectively target retinoid X receptors rather than classic retinoic acid receptors By binding to RXR alpha, beta, and gamma subtypes, these agents facilitate homodimerization or heterodimerization with other nuclear receptors—such as retinoic acid, vitamin D, and peroxisome proliferator-activated receptors—to regulate transcription programs gove...

Selective retinoid X receptor agonists, commonly referred to as rexinoids, are a specialized antineoplastic subclass of synthetic retinoids designed to selectively target retinoid X receptors rather than classic retinoic acid receptors By binding to RXR alpha, beta, and gamma subtypes, these agents facilitate homodimerization or heterodimerization with other nuclear receptors—such as retinoic acid, vitamin D, and peroxisome proliferator-activated receptors—to regulate transcription programs gove...

Clinically, their primary established use is in oncology and dermatology, specifically for treating the manifestations of cutaneous T-cell lymphoma, with ongoing investigation into other malignancies and metabolic conditions