Selective Serotonin Agonists 5-HT1 (Triptans)

Selective serotonin agonists targeting the 5-HT1 receptor family, commonly referred to as triptans, are a drug class primarily indicated for the acute abortive treatment of moderate to severe migraine attacks with or without aura, as well as cluster headaches for select agents These medications exert their therapeutic effects through selective agonism of 5-HT1B and 5-HT1D receptor subtypes, which stimulates cranial vasoconstriction of painfully distended meningeal and intracranial blood vessels

Selective serotonin agonists targeting the 5-HT1 receptor family, commonly referred to as triptans, are a drug class primarily indicated for the acute abortive treatment of moderate to severe migraine attacks with or without aura, as well as cluster headaches for select agents These medications exert their therapeutic effects through selective agonism of 5-HT1B and 5-HT1D receptor subtypes, which stimulates cranial vasoconstriction of painfully distended meningeal and intracranial blood vessels ...

These medications exert their therapeutic effects through selective agonism of 5-HT1B and 5-HT1D receptor subtypes, which stimulates cranial vasoconstriction of painfully distended meningeal and intracranial blood vessels Concurrently, they stimulate presynaptic 5-HT1D receptors on trigeminal nerve terminals, suppressing the release of pro-inflammatory neuropeptides and halting central transmission of pain signals to the brain

Because of their targeted vascular and neurogenic mechanisms, they serve as first-line prescription options for terminating acute cephalic pain rather than for routine headache prophylaxis