Sulfonamides

Sulfonamides are a therapeutic class of synthetic bacteriostatic antimicrobial agents that structurally mimic para-aminobenzoic acid (PABA) They exert their therapeutic effect by competitively inhibiting the bacterial enzyme dihydropteroate synthase, thereby blocking the synthesis of dihydrofolic acid necessary for microbial purine and nucleic acid production Systemic and topical sulfonamides are primarily indicated for the treatment and prevention of urinary tract infections, superficial ocular...

Although historically used as broad-spectrum monotherapy, they are most frequently coadministered today with dihydrofolate reductase inhibitors—such as trimethoprim—to achieve synergistic bactericidal activity against susceptible organisms

Although historically used as broad-spectrum monotherapy, they are most frequently coadministered today with dihydrofolate reductase inhibitors—such as trimethoprim—to achieve synergistic bactericidal activity against susceptible organisms

Although historically used as broad-spectrum monotherapy, they are most frequently coadministered today with dihydrofolate reductase inhibitors—such as trimethoprim—to achieve synergistic bactericidal activity against susceptible organisms Systemic and topical sulfonamides are primarily indicated for the treatment and prevention of urinary tract infections, superficial ocular and burn wound infections, and opportunistic conditions such as *Pneumocystis jirovecii* pneumonia and toxoplasmosis

Systemic and topical sulfonamides are primarily indicated for the treatment and prevention of urinary tract infections, superficial ocular and burn wound infections, and opportunistic conditions such as *Pneumocystis jirovecii* pneumonia and toxoplasmosis