Drug class

Thiazide and Related Diuretics

Thiazide and related diuretics encompass classic benzothiadiazine derivatives, such as hydrochlorothiazide, along with chemically distinct thiazide-like agents like chlorthalidone, indapamide, and metolazone that share the same pharmacologic profile. Read more about Thiazide and Related Diuretics

295 drugs in this class 106 manufacturers

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Drugs in Thiazide and Related Diuretics

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About Thiazide and Related Diuretics.

Thiazide and related diuretics encompass classic benzothiadiazine derivatives, such as hydrochlorothiazide, along with chemically distinct thiazide-like agents like chlorthalidone, indapamide, and metolazone that share the same pharmacologic profile.

These medications act principally by inhibiting the sodium-chloride cotransporter in the renal distal convoluted tubule, which reduces solute reabsorption and promotes urinary excretion of sodium, chloride, and water.

Clinically, they are primary therapeutic agents used in the management of essential hypertension and are commonly employed to control peripheral or pulmonary edema secondary to congestive heart failure, nephrotic syndrome, and hepatic cirrhosis.