Thiol-Type Renal/Tissue Protectants

Thiol-type renal and tissue protectants—most commonly categorized in standard medical compendia as cytoprotective or chemoprotective agents—are supportive-care drugs designed to shield healthy tissues from the toxic effects of specific antineoplastic therapies

Thiol-type renal and tissue protectants—most commonly categorized in standard medical compendia as cytoprotective or chemoprotective agents—are supportive-care drugs designed to shield healthy tissues from the toxic effects of specific antineoplastic therapies

Representative agents like amifostine are dephosphorylated in tissues to active free thiol metabolites that scavenge reactive oxygen species and bind directly to electrophilic, toxic drug metabolites

Representative agents like amifostine are dephosphorylated in tissues to active free thiol metabolites that scavenge reactive oxygen species and bind directly to electrophilic, toxic drug metabolites By preferentially concentrating in normal nonmalignant cells, they mitigate treatment-limiting toxicities without reducing antineoplastic efficacy

By preferentially concentrating in normal nonmalignant cells, they mitigate treatment-limiting toxicities without reducing antineoplastic efficacy In clinical oncology, they are primarily indicated to prevent cumulative cisplatin-induced nephrotoxicity in advanced ovarian cancer and to reduce radiation-induced xerostomia in head and neck cancer

In clinical oncology, they are primarily indicated to prevent cumulative cisplatin-induced nephrotoxicity in advanced ovarian cancer and to reduce radiation-induced xerostomia in head and neck cancer