Drug class

Thrombin Inhibitors (Non-Heparinoid)

Thrombin inhibitors (non-heparinoid), more formally known as direct thrombin inhibitors (DTIs), are an anticoagulant drug class distinct from heparin and heparinoids because they do not rely on endogenous antithrombin to exert their activity. Read more about Thrombin Inhibitors (Non-Heparinoid)

42 drugs in this class 36 manufacturers

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Drugs in Thrombin Inhibitors (Non-Heparinoid)

Showing 1–9 of 42 drugs

ARGATROBAN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS IN HEPARIN-INDUCED THROMBOCYTOPENIA ·+2
PAR HEALTH USA,

BIVALIRUDIN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS WITH HEPARIN-INDUCED THROMBOCYTOPENIA DURING PERCUTANEOUS CORONARY INTERVENTION ·+2
SANDOZ

BIVALIRUDIN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS WITH HEPARIN-INDUCED THROMBOCYTOPENIA DURING PERCUTANEOUS CORONARY INTERVENTION ·+2
FRESENIUS KABI

BIVALIRUDIN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS WITH HEPARIN-INDUCED THROMBOCYTOPENIA DURING PERCUTANEOUS CORONARY INTERVENTION ·+2
DR.REDDY'S LAB

BIVALIRUDIN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS WITH HEPARIN-INDUCED THROMBOCYTOPENIA DURING PERCUTANEOUS CORONARY INTERVENTION ·+2
APOTEX CORP

ARGATROBAN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS IN HEPARIN-INDUCED THROMBOCYTOPENIA ·+2
MYLAN INSTITUTI

ARGATROBAN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS IN HEPARIN-INDUCED THROMBOCYTOPENIA ·+2
WEST-WARD,INC./

BIVALIRUDIN

THROMBIN INHIBITORS (NON-HEPARINOID) · THROMBOSIS WITH HEPARIN-INDUCED THROMBOCYTOPENIA DURING PERCUTANEOUS CORONARY INTERVENTION ·+2
FRESENIUS KABI
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About Thrombin Inhibitors (Non-Heparinoid).

Thrombin inhibitors (non-heparinoid), more formally known as direct thrombin inhibitors (DTIs), are an anticoagulant drug class distinct from heparin and heparinoids because they do not rely on endogenous antithrombin to exert their activity.

These agents—including parenteral drugs such as argatroban and bivalirudin, as well as the oral agent dabigatran—bind directly and reversibly to the active site or exosite of both circulating and clot-bound thrombin, thereby preventing the conversion of fibrinogen to fibrin and inhibiting thrombin-induced platelet activation.

Clinically, this class serves as an essential therapy for managing thromboembolism in patients with heparin-induced thrombocytopenia, providing procedural anticoagulation during percutaneous coronary intervention, and reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation or deep vein thrombosis.