Drug class

von Willebrand factor

Von Willebrand factor constitutes a therapeutic class of hemostatic replacement biologics that includes plasma-derived concentrates—often formulated in complex with coagulation factor VIII—and recombinant human von Willebrand factor. Read more about von Willebrand factor

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Drugs in von Willebrand factor

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About von Willebrand factor.

Von Willebrand factor constitutes a therapeutic class of hemostatic replacement biologics that includes plasma-derived concentrates—often formulated in complex with coagulation factor VIII—and recombinant human von Willebrand factor.

These agents exert their primary therapeutic role by restoring normal hemostasis, directly mediating platelet adhesion to damaged vascular subendothelium, promoting platelet aggregation, and serving as a stabilizing carrier protein for endogenous factor VIII to prolong its circulatory half-life.

The class is predominantly indicated for the on-demand control of bleeding episodes, perioperative surgical management, and routine bleeding prophylaxis in adult and pediatric patients with von Willebrand disease, as well as selected manifestations of hemophilia A when formulated as a factor VIII complex.