Phospholine Iodide (echothiophate iodide)
Ophthalmic Anticholinesterase Miotics Ophthalmic (Eye) Drops
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: This medication is used to treat high pressure inside the eye (due to conditions such as certain types of glaucoma) and other eye problems (such as accommodative esotropia). It works by causing the pupil to shrink, decreasing the amount of fluid within the eye, and affecting certain eye muscles.
Generic name: echothiophate iodide
Pronunciation: (eck-oh-THIGH-oh-fate)
Drug class: Ophthalmic Anticholinesterase Miotics
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Phospholine Iodide
Indications
The following indications are listed for Phospholine Iodide:
- Esotropia
- Ocular Hypertension
Also known as: Convergent Squint, Convergent Strabismus, Esodeviation, Esophoria, Increased Intraocular Pressure, Increased Iop, Internal Squint, Internal Strabismus, Raised Intraocular Pressure.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Phospholine Iodide 0.125% Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route once daily. |
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
Echothiophate Iodide/Succinylcholine
SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.
MECHANISM OF ACTION: Decreased pseudocholinesterase activity.
CLINICAL EFFECTS: Succinylcholine administered to patients receiving echothiophate are at risk of developing respiratory depression and prolonged periods of apnea, with death a possibility. Effects may be seen for several weeks after stopping the echothiophate.
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: Avoid concomitant use of these agents or use with caution. It is recommended that plasma pseudocholinesterase measurements be taken before succinylcholine is given.
DISCUSSION: This interaction is well documented.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Uveitis
- 30 day risk period post-myocardial infarction
- Angle-closure glaucoma
- Asthma
- Bradycardia
- Diarrhea
- Hyperhidrosis
- Hypertension
- Increased gastric tonus
- Irritable bowel syndrome
- Muscle weakness
- Peptic ulcer
- Retinal detachment
- Salivary secretion disorder
- Seizure disorder
- Severe hypotension
- Urinary incontinence
- Iritis
- Parkinsonism
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Myopia
Less Frequent
- Cataracts
- Corneal opacity
- Iris cyst
- Nasolacrimal duct stenosis
Rare or Very Rare
- Abdominal pain with cramps
- Bradycardia
- Bronchospastic pulmonary disease
- Diarrhea
- Hyperhidrosis
- Muscle weakness
- Nausea
- Ocular irritation
- Ocular pain
- Ocular redness
- Retinal detachment
- Severe hypotension
- Sialorrhea
- Urinary incontinence
- Vomiting
More Frequent
- Blepharospasm
- Eye tearing
- Headache disorder
Less Frequent
- Blurred vision
- Conjunctival hyperemia
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Esotropia | ||
| H50.43 | ICD10CM | Accommodative component in esotropia |
| Ocular hypertension | ||
| H40.05 | ICD10CM | Ocular hypertension |
| H40.051 | ICD10CM | Ocular hypertension, right eye |
| H40.052 | ICD10CM | Ocular hypertension, left eye |
| H40.053 | ICD10CM | Ocular hypertension, bilateral |
| H40.059 | ICD10CM | Ocular hypertension, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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