Alphanate (antihemophilic factor, human/von Willebrand factor,human)
Antihemophilic Products Intravenous Vial (Ea)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Antihemophilic factor (human) is a preparation of antihemophilic factor (blood coagulation factor VIII) prepared from pooled human plasma. Antihemophilic factor/von Willebrand factor complex (human) is a preparation of antihemophilic factor and von Willebrand factor prepared from pooled human plasma.
USES: This product contains human factor VIII (also called antihemophilic factor) and von Willebrand factor complex. Factors are proteins normally found in the blood that help the blood to thicken (clot) and stop any bleeding. People with low levels of factor VIII and von Willebrand factor are at risk for bleeding longer after an injury/surgery and for bleeding inside the body (especially into the joints and muscles).
This product is used to temporarily replace the missing factors and reduce bleeding. Different brands of this product have different amounts of these factors, and so have different uses. These products are not interchangeable.
Do not change brands of this medication without the approval of your doctor. Some products are used to control and prevent bleeding episodes in people with low levels of factor VIII (hemophilia A). Some products are used to control and prevent bleeding episodes in people with low levels of von Willebrand factor (von Willebrand disease).
Some products are used to prevent excessive bleeding during and after surgery in patients with von Willebrand disease.
Generic name: antihemophilic factor, human/von Willebrand factor,human
Pronunciation: (FAK-tor VIII/von-WIL-e-brand FAK-tor)
Drug class: Antihemophilic Products
Therapeutic class: Hematological Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Alphanate
Indications
The following indications are listed for Alphanate:
- Acquired Factor Viii Deficiency Disease
- Bleeding Episode In Acquired Factor Viii Deficiency Disease
- Bleeding Episode In Hemophilia A
- Bleeding Prevention In Von Willebrand Disease Type 3
- Hemophilia A
- Prevention Of Surgery-Induced Bleed In Von Willebrand's Disease
- Von Willebrand's Disease
Also known as: Angiohemophilia, Bleeding Prophylaxis In Type 3 Von Willebrand Disease, Congenital Factor Viii Deficiency Disease, Constitutional Thrombopathy, Hemorrhaging In Hemophilia A, Pseudohemophilia, Vascular Hemophilia, Von Willebrand Disease, Willebrand-Juergens Disease.
Dosing
Dosage of antihemophilic factor (human) and antihemophilic factor/von Willebrand factor complex (human) is expressed in terms of international units (IU, units); 1 unit of antihemophilic factor is approximately equivalent to the amount of factor VIII in 1 mL of fresh pooled human plasma. In general, administration of 1 unit/kg of these antihemophilic factor preparations will increase the circulating factor VIII level by approximately 2 units/dL (2%).
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- Thromboembolic disorder
Adverse reactions
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Less Frequent
- Allergic dermatitis
- Anaphylaxis
- Angioedema
- Dyspnea
- Erythema
- Fibrinogen excess
- Skin rash
- Thrombotic disorder
- Urticaria
Rare or Very Rare
- Acute myocardial infarction
- Cerebrovascular accident
- Chest tightness
- Disseminated intravascular coagulation
- Hemolytic anemia
- Hypersensitivity drug reaction
- Hypertension
- Injection site infection
- Pulmonary thromboembolism
- Thromboembolic disorder
- Wheezing
More Frequent
- Dizziness
- Fever
- Headache disorder
- Injection site sequelae
- Nausea
Less Frequent
- Chest discomfort
- Chills
- Drowsy
- Dyspepsia
- Flushing
- Insomnia
- Lethargy
- Pruritus of skin
- Upper respiratory infection
- Vomiting
Rare or Very Rare
- Acute abdominal pain
- Cough
- Diarrhea
- Dysgeusia
- Fatigue
- Hypotension
- Paresthesia
- Sensation of warmth
- Tachycardia
Precautions
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No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Acquired factor VIII deficiency disease | ||
| D68.311 | ICD10CM | Acquired hemophilia |
| D68.4 | ICD10CM | Acquired coagulation factor deficiency |
| Bleeding episode in acquired factor VIII deficiency disease | ||
| D68.311 | ICD10CM | Acquired hemophilia |
| D68.4 | ICD10CM | Acquired coagulation factor deficiency |
| Bleeding episode in hemophilia A | ||
| D66 | ICD10CM | Hereditary factor VIII deficiency |
| Z14.02 | ICD10CM | Symptomatic hemophilia A carrier |
| Bleeding prevention in von willebrand disease type 3 | ||
| D68.03 | ICD10CM | Von willebrand disease, type 3 |
| Hemophilia A | ||
| D66 | ICD10CM | Hereditary factor VIII deficiency |
| Z14.02 | ICD10CM | Symptomatic hemophilia A carrier |
| Prevention of surgery-induced bleed in von willebrand's disease | ||
| D68.0 | ICD10CM | Von willebrand disease |
| D68.00 | ICD10CM | Von willebrand disease, unspecified |
| D68.01 | ICD10CM | Von willebrand disease, type 1 |
| D68.02 | ICD10CM | Von willebrand disease, type 2 |
| D68.020 | ICD10CM | Von willebrand disease, type 2A |
| D68.021 | ICD10CM | Von willebrand disease, type 2B |
| D68.022 | ICD10CM | Von willebrand disease, type 2M |
| D68.023 | ICD10CM | Von willebrand disease, type 2N |
| D68.029 | ICD10CM | Von willebrand disease, type 2, unspecified |
| D68.03 | ICD10CM | Von willebrand disease, type 3 |
| D68.04 | ICD10CM | Acquired von willebrand disease |
| D68.09 | ICD10CM | Other von willebrand disease |
| Von willebrand's disease | ||
| D68.0 | ICD10CM | Von willebrand disease |
| D68.00 | ICD10CM | Von willebrand disease, unspecified |
| D68.01 | ICD10CM | Von willebrand disease, type 1 |
| D68.02 | ICD10CM | Von willebrand disease, type 2 |
| D68.020 | ICD10CM | Von willebrand disease, type 2A |
| D68.021 | ICD10CM | Von willebrand disease, type 2B |
| D68.022 | ICD10CM | Von willebrand disease, type 2M |
| D68.023 | ICD10CM | Von willebrand disease, type 2N |
| D68.029 | ICD10CM | Von willebrand disease, type 2, unspecified |
| D68.03 | ICD10CM | Von willebrand disease, type 3 |
| D68.04 | ICD10CM | Acquired von willebrand disease |
| D68.09 | ICD10CM | Other von willebrand disease |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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