Zerviate (cetirizine HCl)
Ophthalmic Antiallergic Agents Ophthalmic (Eye) Dropperette, Single-Use Drop Dispenser
Last reviewed · Source: First Databank (FDB) drug data
Overview
Cetirizine hydrochloride is a histamine (H1) receptor antagonist.
Cetirizine is a selective histamine-1 (H1) receptor antagonist. In vivo and ex vivo studies demonstrated negligible anticholinergic and antiserotonergic activity, and in vitro receptor binding studies showed no measurable affinity for receptors other than H1.
The observed mean terminal half-life of cetirizine 0.24% ophthalmic solution was 8.6 hours following a single dose and 8.2 hours after twice-daily dosing of cetirizine for 2 week.
USES: This medication is used to prevent itching of the eyes due to allergies. Cetirizine is an antihistamine. It works by blocking a certain natural substance (histamine) that causes allergic symptoms.
Do not use this medication to treat red or irritated eyes due to wearing contact lenses. Contact your doctor for further instructions if this occurs.
Generic name: cetirizine HCl
Pronunciation: (se-TIR-i-zeen)
Drug class: Ophthalmic Antiallergic Agents
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Zerviate
Indications
The following indications are listed for Zerviate:
- Allergic Conjunctivitis
Also known as: Allergy Eye Itch, Atopic Conjunctivitis, Itchy Eyes Due To Allergies, Ocular Itching Due To Allergies.
Dosing
Dosage of cetirizine hydrochloride is expressed in terms of cetirizine.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Zerviate 0.24% Eye Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route 2 times per day. |
No dosing information is available for this tab.
Drug interactions
No formal drug interaction studies have been performed. No drug-drug interactions have been reported during the clinical development of cetirizine 0.24% ophthalmic solution.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
*None.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- No disease contraindications
Adverse reactions
The most common adverse reactions (1-7%) reported with cetirizine 0.24% ophthalmic solutionin clinical studies were ocular hyperemia, instillation site pain, and reduced visual acuity.
There are no severe adverse reactions for this drug.
More Frequent
- Ocular pain
- Ocular redness
- Reduced visual acuity
Rare or Very Rare
- Anticholinergic toxicity
Precautions
No enhanced messaging available.
Safety and effectiveness of cetirizine 0.24% ophthalmic solution have been established in pediatric patients >=2 years of age.
There are no available data regarding use of cetirizine 0.24% ophthalmic solution in pregnant women to inform any potential drug-associated risk. Cetirizine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Cetirizine has been reported to be excreted in human breast milk following oral administration. Administration of cetirizine 10 mg tablets once daily for 10 days resulted in systemic levels that were 100 times higher than the observed human exposure following twice daily administration of cetirizine ophthalmic solution 0.24% to both eyes for 1 week. It is not known whether topical ocular administration of cetirizine results in detectable levels in human breast milk.
It is not known whether cetirizine 0.24% ophthalmic solution is distributed into human milk, or if the drug has any effects on the breastfed infant or on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for cetirizine and any potential adverse effects on the breastfed child from the drug.
No overall differences in safety or effectiveness have been observed between elderly and younger patients.
ICD codes
| Code | Type | Description |
|---|---|---|
| Allergic conjunctivitis | ||
| H10.1 | ICD10CM | Acute atopic conjunctivitis |
| H10.10 | ICD10CM | Acute atopic conjunctivitis, unspecified eye |
| H10.11 | ICD10CM | Acute atopic conjunctivitis, right eye |
| H10.12 | ICD10CM | Acute atopic conjunctivitis, left eye |
| H10.13 | ICD10CM | Acute atopic conjunctivitis, bilateral |
| H10.44 | ICD10CM | Vernal conjunctivitis |
| H10.45 | ICD10CM | Other chronic allergic conjunctivitis |
| H16.26 | ICD10CM | Vernal keratoconjunctivitis, with limbar and corneal involvement |
| H16.261 | ICD10CM | Vernal keratoconjunctivitis, with limbar and corneal involvement, right eye |
| H16.262 | ICD10CM | Vernal keratoconjunctivitis, with limbar and corneal involvement, left eye |
| H16.263 | ICD10CM | Vernal keratoconjunctivitis, with limbar and corneal involvement, bilateral |
| H16.269 | ICD10CM | Vernal keratoconjunctivitis, with limbar and corneal involvement, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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