Pralidoxime Chloride (pralidoxime chloride)
Organophosphate Poisoning Antidote Intramuscular Pen Injector (Ml)
Last reviewed · Source: First Databank (FDB) drug data
Overview
USES: This medication is used with atropine to treat nerve agent poisoning by certain chemicals known as anticholinesterase agents (such as organophosphate pesticides such as parathion, "nerve gas" such as sarin, other nerve agents such as VX). Pralidoxime works by restoring the activity of a certain natural substance (cholinesterase) needed by nerves and muscles. Symptoms of nerve agent poisoning may include trouble breathing, headache, runny nose, drooling, vision changes, sweating, abdominal cramps, nausea, vomiting, diarrhea, muscle twitching/jerking, drowsiness, confusion, and seizures.
Pralidoxime works mostly on the muscles (including breathing muscles) to decrease twitching, cramping, weakness, and paralysis. Another medication (atropine) is used to treat these and other symptoms of nerve agent poisoning such as slow/shallow breathing, wheezing, increased sweating/saliva, abdominal cramps, vomiting, and diarrhea.
Generic name: pralidoxime chloride
Pronunciation: (PRAL-i-DOX-eem)
Drug class: Organophosphate Poisoning Antidote
Therapeutic class: Antidotes and other Reversal Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Pralidoxime Chloride
Indications
The following indications are listed for Pralidoxime Chloride:
- Cholinesterase Inhibitors Toxicity
- Organophos Insecticide Poisoning
- Organophosphorous Overdose
- Poisoning Due To Nerve Agent
Also known as: Anticholinesterase Agent Poisoning, Organophosphate Poisoning, Poisoning By War Nerve Agent.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- Hypertension
- Kidney disease with reduction in glomerular filtration rate (GFr)
Adverse reactions
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More Frequent
- Blurred vision
- Diplopia
- Dizziness
- Hypertension
- Hyperventilation
- Injection site sequelae
- Laryngismus
- Muscle rigidity
- Muscle weakness
- Reduced visual acuity
- Tachycardia
Less Frequent
- Increased alanine transaminase
- Increased aspartate transaminase
- Kidney disease with reduction in glomerular filtration rate (GFr)
More Frequent
- Drowsy
- Headache disorder
- Increased creatine kinase level
- Nausea
Less Frequent
- Abnormal hepatic function tests
- Accommodation disorder
- Dry skin
- Excitement
- Manic disorder
- Skin rash
- Vomiting
- Xerostomia
Precautions
No enhanced messaging available.
No enhanced messaging available.
Safe use of pralidoxime during pregnancy has not been established.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Cholinesterase inhibitors toxicity | ||
| T44.0x1A | ICD10CM | Poisoning by anticholinesterase agents, accidental (unintentional), initial encounter |
| T44.0x2A | ICD10CM | Poisoning by anticholinesterase agents, intentional self-harm, initial encounter |
| T44.0x3A | ICD10CM | Poisoning by anticholinesterase agents, assault, initial encounter |
| T44.0x4A | ICD10CM | Poisoning by anticholinesterase agents, undetermined, initial encounter |
| Organophos insecticide poisoning | ||
| T60.0 | ICD10CM | Toxic effect of organophosphate and carbamate insecticides |
| T60.0x | ICD10CM | Toxic effect of organophosphate and carbamate insecticides |
| T60.0x1 | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, accidental (unintentional) |
| T60.0x1A | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, accidental (unintentional), initial encounter |
| T60.0x2 | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, intentional self-harm |
| T60.0x2A | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, intentional self-harm, initial encounter |
| T60.0x3 | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, assault |
| T60.0x3A | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, assault, initial encounter |
| T60.0x4 | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, undetermined |
| T60.0x4A | ICD10CM | Toxic effect of organophosphate and carbamate insecticides, undetermined, initial encounter |
| Organophosphorous overdose | ||
| T44.0x1A | ICD10CM | Poisoning by anticholinesterase agents, accidental (unintentional), initial encounter |
| T44.0x2A | ICD10CM | Poisoning by anticholinesterase agents, intentional self-harm, initial encounter |
| T44.0x3A | ICD10CM | Poisoning by anticholinesterase agents, assault, initial encounter |
| T44.0x4A | ICD10CM | Poisoning by anticholinesterase agents, undetermined, initial encounter |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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