Organophosphorous overdose

An organophosphorous overdose is an acute, life-threatening toxic state resulting from exposure to organophosphate compounds commonly encountered in agricultural insecticides, industrial agents, or chemical nerve agents Pathophysiologically, these compounds bind to and inhibit the acetylcholinesterase enzyme at neural synapses and neuromuscular junctions, causing excessive accumulation of acetylcholine across the central, parasympathetic, and sympathetic nervous systems This synaptic hyperstimul...

An organophosphorous overdose is an acute, life-threatening toxic state resulting from exposure to organophosphate compounds commonly encountered in agricultural insecticides, industrial agents, or chemical nerve agents Pathophysiologically, these compounds bind to and inhibit the acetylcholinesterase enzyme at neural synapses and neuromuscular junctions, causing excessive accumulation of acetylcholine across the central, parasympathetic, and sympathetic nervous systems This synaptic hyperstimul...

This synaptic hyperstimulation precipitates an acute cholinergic crisis classically marked by muscarinic hypersecretions (such as bronchorrhea, salivation, lacrimation, and diarrhea), miosis, bradycardia, bronchospasm, and nicotinic manifestations including muscle fasciculations and flaccid weakness

Without prompt intervention, severe cases rapidly progress to central nervous system depression, seizures, and fatal respiratory failure secondary to airway compromise and respiratory muscle paralysis