Atropine Sulfate (atropine sulfate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Atropine (dl-hyoscyamine) is a naturally occurring tertiary amine antimuscarinic.
Generic name: atropine sulfate
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Atropine Sulfate
Indications
The following indications are listed for Atropine Sulfate:
- Cholinesterase Inhibitors Toxicity
- Muscarine Toxicity
- Organophosphorous Overdose
- Reversal Of Neuromuscular Blockade
- Sialorrhea
- Sinus Bradycardia
Also known as: Anticholinesterase Agent Poisoning, Excessive Saliva Secretion, Excessive Salivation, Increased Salivation, Organophosphate Poisoning, Ptyalism, Reversal Of Muscle Blockade, Salivary Hypersecretion.
Dosing
Dosage of atropine sulfate should be individualized based on indication, patient characteristics, and response (e.g., heart rate, blood pressure); pediatric patients tend to be more susceptible than adults to the toxic effects of atropine overdosage.
Atropine sulfate is administered by IM, subcutaneous, or direct IV administration. IV administration is preferred for the treatment of severe or life-threatening muscarinic effects.
Atropine also has been administered by intraosseous (IO) injection+ in the setting of advanced cardiovascular life support (ACLS), generally when IV access is not readily available; onset of action and systemic concentrations are comparable to those achieved with venous administration.
Atropine may be administered via an endotracheal tube when vascular access (IV or IO) is not possible; however, IV or IO administration is preferred because of more predictable drug delivery and pharmacologic effect. (See Pharmacokinetics: Absorption.)
Atropine sulfate has been administered orally; however, an oral dosage form no longer is commercially available in the US.
Atropine sulfate has been administered by oral inhalation using a nebulizer solution; however, a solution for oral inhalation no longer is commercially available in the US.
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Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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