Nasonex (mometasone furoate)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Mometasone furoate is a synthetic nonfluorinated corticosteroid.
Mometasone furoate, a synthetic corticosteroid, is an anti-inflammatory agent. Although the exact mechanism(s) of action of corticosteroids in the treatment of allergic rhinitis is not known, mometasone has been shown to inhibit the expression of inflammatory mediators by cells involved in both the early and late phases of the allergic response. Following 12 months of therapy with mometasone furoate (200 mcg daily) in patients with allergic rhinitis, a marked reduction in intraepithelial eosinophilia and infiltration of inflammatory cells (e.g., eosinophils, lymphocytes, monocytes, neutrophils, plasma cells) in nasal mucosa was observed.
Mometasone furoate has a reported bioavailability of less than 0.1% and is virtually undetectable in plasma following administration of a single 400-mcg intranasal dose in healthy adults.
Mometasone furoate is commercially available as the monohydrate; dosage is calculated on the anhydrous basis.
USES: Mometasone is used to prevent and treat seasonal and year-round allergy symptoms (such as stuffy/runny nose, itching, and sneezing). It is also used to treat certain growths in the nose (nasal polyps). Mometasone belongs to a class of drugs known as corticosteroids.
It works by reducing swelling (inflammation) in the nasal passages.
Generic name: mometasone furoate
Pronunciation: (mow-MET-uh-sown)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Nasonex
Indications
The following indications are listed for Nasonex:
- Allergic Rhinitis
- Allergic Rhinitis Prevention
- Chronic Rhinosinusitis With Nasal Polyposis
Also known as: Allergic Rhinitis Prophylaxis.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Known hypersensitivity to mometasone furoate or any ingredient in the formulation.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Adverse effects occurring in 5% or more of patients receiving mometasone furoate for the treatment of allergic rhinitis include headache, viral infection, pharyngitis, epistaxis/blood-tinged mucus, coughing, and upper respiratory tract infection; in addition, dysmenorrhea, musculoskeletal pain, and sinusitis (in patients 12 years of age or older) and vomiting (in patients 3-11 years of age).
Adverse effects occurring in 5% or more of patients receiving mometasone furoate for the treatment of nasal polyposis and more frequently than with placebo include epistaxis.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
Safety and efficacy of intranasal mometasone furoate not established in children younger than 2 years of age for the treatment of allergic rhinitis or younger than 18 years of age for the treatment of nasal polyposis, respectively. Intranasal corticosteroids, including mometasone furoate, may cause a reduction in growth velocity in pediatric patients. (See General Precautions: Systemic Corticosteroid Effects, in Cautions.)
Category C. (See Users Guide.) Administration of corticosteroids during pregnancy may result in hypoadrenalism in the infant.
Not known whether mometasone furoate is distributed in milk. Caution is advised if the drug is administered in nursing women.
No substantial differences in safety and efficacy relative to younger adults.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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