Chlorpromazine Hcl (chlorpromazine HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Chlorpromazine hydrochloride is a phenothiazine antipsychotic agent.
USES: This medication is used to treat certain mental/mood disorders (such as schizophrenia, psychotic disorders, manic phase of bipolar disorder, severe behavioral problems in children). Chlorpromazine belongs to a class of drugs known as antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Chlorpromazine is also used to control nausea/vomiting, relieve prolonged hiccups, relieve restlessness/anxiety before surgery, and help treat tetanus.
Generic name: chlorpromazine HCl
Pronunciation: (klor-PRO-muh-zeen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Chlorpromazine Hcl
Indications
The following indications are listed for Chlorpromazine Hcl:
- Acute Intermittent Porphyria
- Disruptive Behavior Disorder
- Intractable Hiccups
- Mania Associated With Bipolar Disorder
- Nausea And Vomiting
- Pre-Op Apprehension
- Psychotic Disorder
- Schizophrenia
Also known as: Acute Porphyria, Bipolar Mania, Delusional, Dementia Praecox, Mania Associated With Bipolar Affective Disorder, Manic Episode Associated With Bipolar Disorder, Manic Phase Bipolar Mood Disorder, Manic Phase Of Bipolar Mood Disorder, Manic Phase Of Manic-Depression, Parergasia, Persistent Hiccups, Pre-Operative Apprehension, Preoperative Apprehension, Psychosis, Psychotic, Psychotic Disturbance, Pyrroloporphyria, Swedish Porphyria.
Dosing
Dosage of chlorpromazine hydrochloride is expressed in terms of the hydrochloride salt.
The manufacturers state that the 100- and 200-mg tablets of chlorpromazine hydrochloride are intended for use in patients with severe neuropsychiatric conditions.
Dosage must be carefully adjusted according to individual requirements and response, using the lowest possible effective dosage. Dosage should be increased more gradually in debilitated, emaciated, or geriatric patients. Since geriatric patients may be more susceptible to hypotension and neuromuscular reactions, these patients should be observed closely; in general, dosages in the lower end of the range are sufficient for most geriatric patients. Because of the risk of adverse reactions associated with cumulative effects of phenothiazines, patients with a history of long-term therapy with chlorpromazine and/or other antipsychotic agents should be evaluated periodically to determine whether maintenance dosage should be decreased or drug therapy discontinued. Chlorpromazine should generally not be used in children younger than 6 months of age unless the condition to be treated is potentially life-threatening; dosage in this age group has not been established.
Chlorpromazine hydrochloride may be administered orally, by deep IM or direct IV injection, or by IV infusion. Direct IV injection is intended for use only during surgery to control nausea and vomiting and in the adjunctive treatment of tetanus. IV infusion is only intended for use in the adjunctive treatment of intractable hiccups in adults. Subcutaneous administration of the drug is not recommended because of local irritation. Parenteral therapy should be reserved for recumbent patients; however, if cautions are taken to avoid orthostatic hypotension (i.e., patient remains recumbent for at least 30 minutes after injection), acutely agitated ambulatory patients may receive the drug IM.
For IM administration, injection should be made slowly, deep into a large muscle mass such as the upper outer quadrant of the gluteus maximus; if irritation at the IM injection site is a problem, the drug can be diluted with 0.9% sodium chloride injection or 2% procaine hydrochloride. For direct IV injection, chlorpromazine hydrochloride injection should be diluted with 0.9% sodium chloride injection to a concentration not exceeding 1 mg/mL and administered at a rate of 1 mg/minute in adults and 0.5 mg/minute in children. IV administration of undiluted chlorpromazine hydrochloride injection should be avoided. For IV infusion, chlorpromazine hydrochloride injection should be added to 500-1000 mL of 0.9% sodium chloride injection and administered slowly.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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