DASATINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+4
AVKARE
Indication
Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood. Read more about Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia
56 drugs 40 manufacturers
Drugs that treat it
Common Accelerated phase Philadelphia chromosome positive chronic myelocytic leukemia therapies.
GLEEVEC (imatinib mesylate)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
Novartis Pharmaceuticals
TASIGNA (nilotinib HCl)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+1
Novartis Pharmaceuticals
NILOTINIB HCL
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+1
AVKARE
IMATINIB MESYLATE
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
SAFECOR HEALTH
BOSUTINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·LYMPHOID BLAST PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+3
ALEMBIC PHARMAC
DASATINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+4
NORTHSTAR RX LL
BOSUTINIB
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·LYMPHOID BLAST PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+3
DR.REDDY'S LAB
CAVHANZA (nilotinib)
ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·CHRONIC PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOCYTIC LEUKEMIA·+1
CYCLE PHARMACEU
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Coming soonAccelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood.
It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase.
The accelerated phase represents disease evolution beyond the indolent chronic phase toward acute blast transformation, characterized clinically by treatment-refractory leukocytosis or splenomegaly, elevated blast counts (typically 10% to 19%), persistent thrombocytosis or thrombocytopenia, prominent basophilia, and frequent cytogenetic clonal evolution.
- nih.gov
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase
- nih.gov
Accelerated phase Philadelphia chromosome-positive chronic myelocytic leukemia is an advanced, transitional stage of a clonal myeloproliferative neoplasm affecting hematopoietic stem cells in the bone marrow and peripheral blood The accelerated phase represents disease evolution beyond the indolent chronic phase toward acute blast transformation, characterized clinically by treatment-refractory leukocytosis or splenomegaly, elevated blast counts (typically 10% to 19%), persistent thrombocytosis ...
- nih.gov
It is pathologically driven by the BCR::ABL1 fusion gene resulting from the reciprocal t(9;22)(q34;q11) translocation, known as the Philadelphia chromosome, which encodes a constitutively active tyrosine kinase
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