Adjunct therapy for irritable bowel syndrome

Irritable bowel syndrome is a chronic disorder of gut-brain interaction that predominantly affects the gastrointestinal tract in adults, with a higher prevalence observed in females

Irritable bowel syndrome is a chronic disorder of gut-brain interaction that predominantly affects the gastrointestinal tract in adults, with a higher prevalence observed in females It is clinically characterized by recurrent abdominal pain related to defecation, accompanied by changes in stool frequency or form, manifesting as constipation-predominant, diarrhea-predominant, or mixed bowel habit patterns The underlying pathophysiology involves dysregulated bidirectional communication along the b...

It is clinically characterized by recurrent abdominal pain related to defecation, accompanied by changes in stool frequency or form, manifesting as constipation-predominant, diarrhea-predominant, or mixed bowel habit patterns

The underlying pathophysiology involves dysregulated bidirectional communication along the brain-gut axis, gastrointestinal motility disturbances, visceral hypersensitivity, low-grade mucosal inflammation, altered intestinal permeability, and gut microbiome dysbiosis

In the context of adjunct therapy, pharmacological interventions are utilized as supplemental, secondary measures alongside standard lifestyle, dietary, or primary symptom-directed therapies to control refractory manifestations such as acute visceral hyperalgesia, abdominal cramping, or persistent motility abnormalities

In the context of adjunct therapy, pharmacological interventions are utilized as supplemental, secondary measures alongside standard lifestyle, dietary, or primary symptom-directed therapies to control refractory manifestations such as acute visceral hyperalgesia, abdominal cramping, or persistent motility abnormalities