Anaplastic astrocytoma

Anaplastic astrocytoma is a malignant, diffusely infiltrating primary brain tumor arising from glial support cells known as astrocytes

Anaplastic astrocytoma is a malignant, diffusely infiltrating primary brain tumor arising from glial support cells known as astrocytes Patients typically present with progressive focal neurological deficits, persistent headaches, cognitive or behavioral changes, and new-onset seizures secondary to localized tissue infiltration and elevated intracranial pressure

Classified historically as a World Health Organization grade III glioma, it most frequently occurs in adults and primarily affects the cerebral hemispheres, though it can arise throughout the central nervous system

Classified historically as a World Health Organization grade III glioma, it most frequently occurs in adults and primarily affects the cerebral hemispheres, though it can arise throughout the central nervous system

Pathophysiologically, the tumor is characterized by increased cellularity, marked nuclear atypia, and brisk mitotic activity without the prominent microvascular proliferation or necrosis that defines grade IV glioblastoma

Pathophysiologically, the tumor is characterized by increased cellularity, marked nuclear atypia, and brisk mitotic activity without the prominent microvascular proliferation or necrosis that defines grade IV glioblastoma