Indication

Anaplastic lymphoma kinase positive non-small cell lung cancer

Anaplastic lymphoma kinase-positive non-small cell lung cancer is a distinct molecular subtype of non-small cell lung cancer that affects the pulmonary epithelial tissue. Read more about Anaplastic lymphoma kinase positive non-small cell lung cancer

14 drugs 10 manufacturers

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Drugs that treat it

Common Anaplastic lymphoma kinase positive non-small cell lung cancer therapies.

Showing 1–9 of 14 drugs

XALKORI (crizotinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER·+3
Parke-Davis Pfizer

ZYKADIA (ceritinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
Novartis Pharmaceuticals

ALECENSA (alectinib HCl)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
GENENTECH

ALUNBRIG (brigatinib)

ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
Takeda Pharmaceuticals America

ALUNBRIG (brigatinib)

ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
Takeda Pharmaceuticals America

ALUNBRIG (brigatinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
MILLENNIUM PHAR

ALUNBRIG (brigatinib)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·ANAPLASTIC LYMPHOMA KINASE POSITIVE NON-SMALL CELL LUNG CANCER
MILLENNIUM PHAR
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About Anaplastic lymphoma kinase positive non-small cell lung cancer.

Anaplastic lymphoma kinase-positive non-small cell lung cancer is a distinct molecular subtype of non-small cell lung cancer that affects the pulmonary epithelial tissue.

It is defined by chromosomal rearrangements in the *ALK* gene—most commonly a fusion with the *EML4* gene—that produce a chimeric receptor tyrosine kinase with constitutive oncogenic activity, driving unregulated cellular proliferation and survival.

Representing approximately three to five percent of non-small cell lung cancer cases, it predominantly manifests as lung adenocarcinoma and occurs disproportionately in younger adults and individuals with light or no history of tobacco use.

Clinically, these tumors frequently present at an advanced or metastatic stage, displaying a notable propensity for central nervous system involvement.

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