Antibiotic-induced hypoprothrombinemia

Antibiotic-induced hypoprothrombinemia is an acquired hematologic coagulopathy characterized by an absolute or functional deficiency of circulating prothrombin (factor II) and other vitamin K–dependent clotting factors following antimicrobial therapy Pathophysiologically, the condition arises from the suppression of vitamin K–producing intestinal microflora, direct drug inhibition of hepatic vitamin K–dependent gamma-carboxylation, or disruption of the vitamin K epoxide reductase cycle

Antibiotic-induced hypoprothrombinemia is an acquired hematologic coagulopathy characterized by an absolute or functional deficiency of circulating prothrombin (factor II) and other vitamin K–dependent clotting factors following antimicrobial therapy

It primarily affects the hematologic system, commonly manifesting in hospitalized, elderly, critically ill, or malnourished patients receiving broad-spectrum regimens or agents containing an N-methylthiotetrazole (NMTT) side chain

It primarily affects the hematologic system, commonly manifesting in hospitalized, elderly, critically ill, or malnourished patients receiving broad-spectrum regimens or agents containing an N-methylthiotetrazole (NMTT) side chain Pathophysiologically, the condition arises from the suppression of vitamin K–producing intestinal microflora, direct drug inhibition of hepatic vitamin K–dependent gamma-carboxylation, or disruption of the vitamin K epoxide reductase cycle

Clinically, it is defined by prolongation of the prothrombin time (PT) and international normalized ratio (INR), predisposing affected individuals to an increased risk of mucocutaneous, gastrointestinal, or surgical bleeding

Clinically, it is defined by prolongation of the prothrombin time (PT) and international normalized ratio (INR), predisposing affected individuals to an increased risk of mucocutaneous, gastrointestinal, or surgical bleeding