Arteriosclerotic parkinsonism

Arteriosclerotic parkinsonism, historically referred to as vascular parkinsonism or arteriosclerotic pseudoparkinsonism, is a secondary parkinsonian syndrome of the central nervous system predominantly affecting older adults with underlying cerebrovascular disease

Arteriosclerotic parkinsonism, historically referred to as vascular parkinsonism or arteriosclerotic pseudoparkinsonism, is a secondary parkinsonian syndrome of the central nervous system predominantly affecting older adults with underlying cerebrovascular disease It is pathophysiologically characterized by ischemic injury—such as diffuse subcortical white matter ischemia and lacunar infarcts within the basal ganglia—that disrupts frontal-subcortical and striato-pallido-thalamocortical motor net...

Arteriosclerotic parkinsonism, historically referred to as vascular parkinsonism or arteriosclerotic pseudoparkinsonism, is a secondary parkinsonian syndrome of the central nervous system predominantly affecting older adults with underlying cerebrovascular disease

It is pathophysiologically characterized by ischemic injury—such as diffuse subcortical white matter ischemia and lacunar infarcts within the basal ganglia—that disrupts frontal-subcortical and striato-pallido-thalamocortical motor networks Clinically, it manifests as a symmetrical, lower-body parkinsonism characterized by early gait impairment, postural instability, and frequent falls, typically with an absence of resting tremor and poor responsiveness to dopaminergic therapy

Clinically, it manifests as a symmetrical, lower-body parkinsonism characterized by early gait impairment, postural instability, and frequent falls, typically with an absence of resting tremor and poor responsiveness to dopaminergic therapy Associated neurological features frequently include pyramidal tract signs, pseudobulbar palsy, urinary dysfunction, and subcortical cognitive decline

Associated neurological features frequently include pyramidal tract signs, pseudobulbar palsy, urinary dysfunction, and subcortical cognitive decline