Bacterial skin and skin structure infection

A bacterial skin and skin structure infection is a microbial invasion affecting the epidermis, dermis, subcutaneous tissues, or deeper soft-tissue structures They are predominantly driven by Gram-positive pathogens, notably *Staphylococcus aureus*—including methicillin-resistant strains—and *Streptococcus pyogenes*, with Gram-negative or anaerobic organisms occasionally implicated in deeper or compromised sites

A bacterial skin and skin structure infection is a microbial invasion affecting the epidermis, dermis, subcutaneous tissues, or deeper soft-tissue structures Pathophysiologically, pathogen entry through a disrupted epithelial barrier triggers localized tissue inflammation, induration, erythema, edema, warmth, and pain, occasionally progressing to purulent drainage, tissue necrosis, or systemic inflammatory response

Occurring across pediatric and adult populations, these infections commonly manifest as cellulitis, erysipelas, cutaneous abscesses, or wound infections They are predominantly driven by Gram-positive pathogens, notably *Staphylococcus aureus*—including methicillin-resistant strains—and *Streptococcus pyogenes*, with Gram-negative or anaerobic organisms occasionally implicated in deeper or compromised sites Pathophysiologically, pathogen entry through a disrupted epithelial barrier triggers local...

Occurring across pediatric and adult populations, these infections commonly manifest as cellulitis, erysipelas, cutaneous abscesses, or wound infections