Bilateral anorchia

Bilateral anorchia, also known as vanishing testis syndrome or testicular regression syndrome, is a rare 46,XY disorder of sexual development characterized by the complete absence of functional testicular tissue at birth in phenotypic males Clinically, affected individuals present with an empty scrotum, occasional micropenis, and hypergonadotropic hypogonadism manifested by undetectable anti-Müllerian hormone and testosterone alongside markedly elevated follicle-stimulating hormone and luteinizi...

Bilateral anorchia, also known as vanishing testis syndrome or testicular regression syndrome, is a rare 46,XY disorder of sexual development characterized by the complete absence of functional testicular tissue at birth in phenotypic males

Bilateral anorchia, also known as vanishing testis syndrome or testicular regression syndrome, is a rare 46,XY disorder of sexual development characterized by the complete absence of functional testicular tissue at birth in phenotypic males

Pathophysiologically, functional embryonic testes are initially present to drive normal male internal and external genital differentiation, but subsequent vascular compromise, intrauterine torsion, or genetic defects trigger regression and atrophy during the second or third trimester Clinically, affected individuals present with an empty scrotum, occasional micropenis, and hypergonadotropic hypogonadism manifested by undetectable anti-Müllerian hormone and testosterone alongside markedly elevate...

Pathophysiologically, functional embryonic testes are initially present to drive normal male internal and external genital differentiation, but subsequent vascular compromise, intrauterine torsion, or genetic defects trigger regression and atrophy during the second or third trimester

Clinically, affected individuals present with an empty scrotum, occasional micropenis, and hypergonadotropic hypogonadism manifested by undetectable anti-Müllerian hormone and testosterone alongside markedly elevated follicle-stimulating hormone and luteinizing hormone levels