Chloroquine-resistant Plasmodium falciparum malaria

Chloroquine-resistant *Plasmodium falciparum* malaria is an acute, potentially life-threatening parasitic bloodstream infection caused by *Plasmodium falciparum* strains that survive therapeutic concentrations of the standard 4-aminoquinoline agent chloroquine

Chloroquine-resistant *Plasmodium falciparum* malaria is an acute, potentially life-threatening parasitic bloodstream infection caused by *Plasmodium falciparum* strains that survive therapeutic concentrations of the standard 4-aminoquinoline agent chloroquine

Transmitted by the bite of infective female *Anopheles* mosquitoes, the protozoan invades and destroys host erythrocytes, with resistance pathophysiologically driven primarily by point mutations in the parasite's *pfcrt* gene that reduce chloroquine accumulation within its digestive vacuole

Transmitted by the bite of infective female *Anopheles* mosquitoes, the protozoan invades and destroys host erythrocytes, with resistance pathophysiologically driven primarily by point mutations in the parasite's *pfcrt* gene that reduce chloroquine accumulation within its digestive vacuole

Transmitted by the bite of infective female *Anopheles* mosquitoes, the protozoan invades and destroys host erythrocytes, with resistance pathophysiologically driven primarily by point mutations in the parasite's *pfcrt* gene that reduce chloroquine accumulation within its digestive vacuole