Cholera

Cholera is an acute intestinal infection caused by the ingestion of food or water contaminated with toxigenic strains of the bacterium *Vibrio cholerae*, primarily serogroups O1 and O139 It predominantly impacts populations in areas with inadequate sanitation and limited access to safe drinking water, affecting both pediatric and adult hosts This results in profuse, secretory "rice-water" diarrhea and vomiting, which can rapidly precipitate severe isonatremic dehydration, electrolyte imbalances,...

Cholera is an acute intestinal infection caused by the ingestion of food or water contaminated with toxigenic strains of the bacterium *Vibrio cholerae*, primarily serogroups O1 and O139 This results in profuse, secretory "rice-water" diarrhea and vomiting, which can rapidly precipitate severe isonatremic dehydration, electrolyte imbalances, hypovolemic shock, and death if untreated

Cholera is an acute intestinal infection caused by the ingestion of food or water contaminated with toxigenic strains of the bacterium *Vibrio cholerae*, primarily serogroups O1 and O139 It predominantly impacts populations in areas with inadequate sanitation and limited access to safe drinking water, affecting both pediatric and adult hosts

Pathophysiologically, the bacterium colonizes the small intestine and secretes cholera enterotoxin, which drives mucosal adenylate cyclase activation, hypersecretion of chloride ions, and impaired sodium chloride absorption This results in profuse, secretory "rice-water" diarrhea and vomiting, which can rapidly precipitate severe isonatremic dehydration, electrolyte imbalances, hypovolemic shock, and death if untreated

Pathophysiologically, the bacterium colonizes the small intestine and secretes cholera enterotoxin, which drives mucosal adenylate cyclase activation, hypersecretion of chloride ions, and impaired sodium chloride absorption