Chorea associated with Huntington's disease

Chorea associated with Huntington's disease is a hyperkinetic movement manifestation of an inherited, autosomal dominant neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the *HTT* gene

Chorea associated with Huntington's disease is a hyperkinetic movement manifestation of an inherited, autosomal dominant neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in the *HTT* gene It primarily affects the central nervous system, driven pathologically by the selective degeneration of GABAergic medium spiny neurons within the striatum and basal ganglia motor circuitry

It primarily affects the central nervous system, driven pathologically by the selective degeneration of GABAergic medium spiny neurons within the striatum and basal ganglia motor circuitry Clinically, it presents as involuntary, rapid, non-stereotyped, and irregular jerking or writhing movements involving the face, trunk, and extremities that progressively disrupt voluntary motor control, gait, and daily functioning

Clinically, it presents as involuntary, rapid, non-stereotyped, and irregular jerking or writhing movements involving the face, trunk, and extremities that progressively disrupt voluntary motor control, gait, and daily functioning

Clinically, it presents as involuntary, rapid, non-stereotyped, and irregular jerking or writhing movements involving the face, trunk, and extremities that progressively disrupt voluntary motor control, gait, and daily functioning