Chronic iron overload due to repeated blood transfusions

Chronic iron overload due to repeated blood transfusions is an acquired systemic disorder characterized by the progressive accumulation of excess iron in parenchymal tissues, occurring in patients requiring long-term transfusion therapy for chronic refractory anemias such as beta-thalassemia, sickle cell disease, or myelodysplastic syndromes This unbuffered reactive iron induces cellular oxidative stress and lipid peroxidation, leading to systemic organ injury, predominantly affecting the liver,...

Chronic iron overload due to repeated blood transfusions is an acquired systemic disorder characterized by the progressive accumulation of excess iron in parenchymal tissues, occurring in patients requiring long-term transfusion therapy for chronic refractory anemias such as beta-thalassemia, sickle cell disease, or myelodysplastic syndromes If left untreated, the cumulative toxicity can cause severe end-organ complications, including hepatic fibrosis or cirrhosis, cardiac dysrhythmias and heart...

Because the human body lacks an active physiologic excretion pathway for excess iron, repeated infusions of donor erythrocytes eventually saturate serum transferrin, resulting in circulating non-transferrin-bound iron

Because the human body lacks an active physiologic excretion pathway for excess iron, repeated infusions of donor erythrocytes eventually saturate serum transferrin, resulting in circulating non-transferrin-bound iron This unbuffered reactive iron induces cellular oxidative stress and lipid peroxidation, leading to systemic organ injury, predominantly affecting the liver, myocardium, and endocrine glands