Chronic lymphocytic leukemia

Chronic lymphocytic leukemia is an indolent hematologic malignancy characterized by the progressive clonal proliferation and accumulation of morphologically mature, immunologically dysfunctional CD5-positive B lymphocytes Primarily affecting older adults, it involves the peripheral blood, bone marrow, spleen, and lymphoid tissues Defining clinical and pathophysiologic features include sustained peripheral absolute lymphocytosis, progressive bone marrow infiltration leading to cytopenias, painles...

Chronic lymphocytic leukemia is an indolent hematologic malignancy characterized by the progressive clonal proliferation and accumulation of morphologically mature, immunologically dysfunctional CD5-positive B lymphocytes Defining clinical and pathophysiologic features include sustained peripheral absolute lymphocytosis, progressive bone marrow infiltration leading to cytopenias, painless lymphadenopathy, hepatosplenomegaly, and increased susceptibility to infections secondary to impaired immune...

Primarily affecting older adults, it involves the peripheral blood, bone marrow, spleen, and lymphoid tissues