Indication

Cluster headache

Cluster headache is a severe primary neurovascular disorder classified among the trigeminal autonomic cephalalgias, most commonly presenting in young to middle-aged adults with a notable male predominance. Read more about Cluster headache

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About Cluster headache.

Cluster headache is a severe primary neurovascular disorder classified among the trigeminal autonomic cephalalgias, most commonly presenting in young to middle-aged adults with a notable male predominance.

It is characterized by recurrent attacks of excruciating, strictly unilateral pain centered in the orbital, supraorbital, or temporal regions that typically last between 15 and 180 minutes.

Pathophysiologically, the condition involves activation of the trigeminovascular system, parasympathetic autonomic pathways, and hypothalamic dysfunction, which governs its marked circadian and circannual periodicity.

Attacks frequently occur in cyclical bouts separated by remission periods and are accompanied by prominent ipsilateral cranial autonomic features, such as conjunctival injection, lacrimation, nasal congestion, ptosis, and pronounced psychomotor agitation or restlessness.

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