Indication

Constipation predominant irritable bowel syndrome

Constipation-predominant irritable bowel syndrome (IBS-C) is a chronic disorder of gut-brain interaction affecting the gastrointestinal tract, characterized by recurrent abdominal pain linked to defecation and prolonged periods of constipation. Read more about Constipation predominant irritable bowel syndrome

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Drugs that treat it

Common Constipation predominant irritable bowel syndrome therapies.

Showing 1–9 of 26 drugs

TRULANCE (plecanatide)

IRRITABLE BOWEL SYNDROME AGENTS·CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME·+1
SALIX/BAUSCH HE

AMITIZA (lubiprostone)

IRRITABLE BOWEL SYNDROME AGENTS·CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME·+2
Takeda Pharmaceuticals America

LINZESS (linaclotide)

IRRITABLE BOWEL SYNDROME AGENTS·CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME·+2
Allergan
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About Constipation predominant irritable bowel syndrome.

Constipation-predominant irritable bowel syndrome (IBS-C) is a chronic disorder of gut-brain interaction affecting the gastrointestinal tract, characterized by recurrent abdominal pain linked to defecation and prolonged periods of constipation.

Defined by standard diagnostic criteria (such as Rome IV), it is clinically distinguished by hard or lumpy stools occurring in at least 25% of bowel movements alongside loose stools occurring in fewer than 25%, frequently accompanied by abdominal bloating and straining.

The condition most commonly impacts adults, with a notable predominance in women.

Its complex pathophysiology involves delayed colonic transit, visceral hypersensitivity, dysregulated epithelial secretion, mucosal immune activation, and disrupted signaling along the bidirectional brain-gut axis.

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