Indication

Dementia associated with Parkinson's disease

Dementia associated with Parkinson's disease is an acquired, progressive neurocognitive syndrome affecting individuals with established Parkinson's disease, typically developing several years after the onset of motor symptoms. Read more about Dementia associated with Parkinson's disease

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About Dementia associated with Parkinson's disease.

Dementia associated with Parkinson's disease is an acquired, progressive neurocognitive syndrome affecting individuals with established Parkinson's disease, typically developing several years after the onset of motor symptoms.

It is primarily characterized by subcortical and frontal-executive cognitive deficits—marked by prominent impairments in attention, executive function, processing speed, and visuospatial abilities, frequently accompanied by visual hallucinations and fluctuating alertness.

Pathophysiologically, the central nervous system undergoes widespread neurodegeneration driven by the propagation of cortical and limbic alpha-synuclein aggregates (Lewy bodies and Lewy neurites), compounded by profound cholinergic deficits originating from the basal forebrain.

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