Diabetic peripheral neuropathy

Diabetic peripheral neuropathy is a chronic microvascular complication of diabetes mellitus characterized by progressive, length-dependent nerve injury to the peripheral nervous system Driven primarily by sustained hyperglycemia, oxidative stress, and microcirculatory impairment, the condition commonly manifests as a distal symmetric polyneuropathy that begins in the toes and lower extremities before advancing proximally in a characteristic stocking-and-glove distribution Clinically, affected in...

Diabetic peripheral neuropathy is a chronic microvascular complication of diabetes mellitus characterized by progressive, length-dependent nerve injury to the peripheral nervous system Clinically, affected individuals may experience positive sensory symptoms—such as burning pain, paresthesias, hyperalgesia, and allodynia—or negative symptoms, including numbness and sensory loss that increase the risk of ulceration and limb amputation

Diabetic peripheral neuropathy is a chronic microvascular complication of diabetes mellitus characterized by progressive, length-dependent nerve injury to the peripheral nervous system Driven primarily by sustained hyperglycemia, oxidative stress, and microcirculatory impairment, the condition commonly manifests as a distal symmetric polyneuropathy that begins in the toes and lower extremities before advancing proximally in a characteristic stocking-and-glove distribution Clinically, affected in...

Driven primarily by sustained hyperglycemia, oxidative stress, and microcirculatory impairment, the condition commonly manifests as a distal symmetric polyneuropathy that begins in the toes and lower extremities before advancing proximally in a characteristic stocking-and-glove distribution