Diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma is an aggressive malignancy of the lymphatic system and the most common subtype of non-Hodgkin lymphoma, predominantly affecting older adults It arises from mature B lymphocytes at various stages of differentiation, most notably classified by cell of origin into germinal center B-cell-like and activated B-cell-like phenotypes

Diffuse large B-cell lymphoma is an aggressive malignancy of the lymphatic system and the most common subtype of non-Hodgkin lymphoma, predominantly affecting older adults

It arises from mature B lymphocytes at various stages of differentiation, most notably classified by cell of origin into germinal center B-cell-like and activated B-cell-like phenotypes Pathophysiologically, it is characterized by the diffuse proliferation of abnormally large B cells that obliterate normal lymph node architecture or infiltrate extranodal sites

Pathophysiologically, it is characterized by the diffuse proliferation of abnormally large B cells that obliterate normal lymph node architecture or infiltrate extranodal sites

Clinically, patients typically present with rapidly enlarging nodal or extranodal masses, which may be accompanied by constitutional B symptoms such as fever, drenching night sweats, and unintentional weight loss

Clinically, patients typically present with rapidly enlarging nodal or extranodal masses, which may be accompanied by constitutional B symptoms such as fever, drenching night sweats, and unintentional weight loss