Drug-induced extrapyramidal reaction

A drug-induced extrapyramidal reaction is an iatrogenic movement disorder affecting the central nervous system, particularly the basal ganglia and extrapyramidal motor pathways

Most commonly triggered by dopamine receptor-blocking agents—such as typical and atypical antipsychotics, antiemetics, and prokinetic agents—this condition results from disrupted nigrostriatal dopaminergic signaling and an imbalance between dopamine and acetylcholine Clinically, reactions can present acutely or chronically and include hypokinetic or hyperkinetic manifestations such as acute dystonia, akathisia, drug-induced parkinsonism (bradykinesia, rigidity, and resting tremor), and tardive d...

Most commonly triggered by dopamine receptor-blocking agents—such as typical and atypical antipsychotics, antiemetics, and prokinetic agents—this condition results from disrupted nigrostriatal dopaminergic signaling and an imbalance between dopamine and acetylcholine

Clinically, reactions can present acutely or chronically and include hypokinetic or hyperkinetic manifestations such as acute dystonia, akathisia, drug-induced parkinsonism (bradykinesia, rigidity, and resting tremor), and tardive dyskinesia

Patients undergoing psychotropic or antiemetic therapy across all age groups may be affected, presenting with involuntary muscle contractions, restlessness, or impaired motor coordination

Patients undergoing psychotropic or antiemetic therapy across all age groups may be affected, presenting with involuntary muscle contractions, restlessness, or impaired motor coordination