Ductal carcinoma in situ of breast

Ductal carcinoma in situ of the breast is a non-invasive, pre-invasive neoplastic proliferation of epithelial cells originating within the breast’s ductal-lobular system The defining hallmark is the malignant transformation of cells lining the milk ducts without penetration through the basement membrane into the surrounding mammary stroma, lymphatic channels, or blood vessels Pathophysiologically categorized as stage 0 breast cancer, it predominantly affects adult women and represents a potentia...

Ductal carcinoma in situ of the breast is a non-invasive, pre-invasive neoplastic proliferation of epithelial cells originating within the breast’s ductal-lobular system Pathophysiologically categorized as stage 0 breast cancer, it predominantly affects adult women and represents a potential, non-obligate precursor to invasive ductal carcinoma

The defining hallmark is the malignant transformation of cells lining the milk ducts without penetration through the basement membrane into the surrounding mammary stroma, lymphatic channels, or blood vessels

The defining hallmark is the malignant transformation of cells lining the milk ducts without penetration through the basement membrane into the surrounding mammary stroma, lymphatic channels, or blood vessels

Although usually asymptomatic and most often identified by characteristic microcalcifications on screening mammography, the lesion is biologically heterogeneous with variable nuclear grade, architectural patterns, and hormone receptor expression