Duodenal ulcer

A duodenal ulcer is a form of peptic ulcer disease characterized by a distinct mucosal break in the duodenum, primarily within the duodenal bulb, that extends beyond the muscularis mucosae If left untreated, duodenal ulcers can progress to severe complications, including upper gastrointestinal hemorrhage, luminal perforation, and gastric outlet obstruction

A duodenal ulcer is a form of peptic ulcer disease characterized by a distinct mucosal break in the duodenum, primarily within the duodenal bulb, that extends beyond the muscularis mucosae It arises within the gastrointestinal tract when the balance between aggressive luminal factors—principally gastric acid and pepsin—and local mucosal defenses is disrupted, predominantly driven by *Helicobacter pylori* infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs) Clinically, it typical...

A duodenal ulcer is a form of peptic ulcer disease characterized by a distinct mucosal break in the duodenum, primarily within the duodenal bulb, that extends beyond the muscularis mucosae

It arises within the gastrointestinal tract when the balance between aggressive luminal factors—principally gastric acid and pepsin—and local mucosal defenses is disrupted, predominantly driven by *Helicobacter pylori* infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs)

Clinically, it typically manifests as burning epigastric pain that occurs two to three hours after eating or during the night and is classically relieved by food intake or antacids

Clinically, it typically manifests as burning epigastric pain that occurs two to three hours after eating or during the night and is classically relieved by food intake or antacids

If left untreated, duodenal ulcers can progress to severe complications, including upper gastrointestinal hemorrhage, luminal perforation, and gastric outlet obstruction