Eclampsia of pregnancy

Eclampsia of pregnancy is a severe, life-threatening hypertensive complication of gestation characterized by the new onset of generalized tonic-clonic seizures or unexplained coma in a pregnant individual with preeclampsia, occurring in the absence of other neurological conditions It primarily impacts the maternal central nervous and cardiovascular systems, typically manifesting after 20 weeks of gestation, intrapartum, or in the early postpartum period Clinically, these seizures are often prece...

Eclampsia of pregnancy is a severe, life-threatening hypertensive complication of gestation characterized by the new onset of generalized tonic-clonic seizures or unexplained coma in a pregnant individual with preeclampsia, occurring in the absence of other neurological conditions It primarily impacts the maternal central nervous and cardiovascular systems, typically manifesting after 20 weeks of gestation, intrapartum, or in the early postpartum period Pathophysiologically, it is driven by syst...

Eclampsia of pregnancy is a severe, life-threatening hypertensive complication of gestation characterized by the new onset of generalized tonic-clonic seizures or unexplained coma in a pregnant individual with preeclampsia, occurring in the absence of other neurological conditions Clinically, these seizures are often preceded by premonitory symptoms such as severe, persistent headaches, visual disturbances, epigastric pain, and marked hypertension, presenting acute risks of maternal hypoxia, int...

It primarily impacts the maternal central nervous and cardiovascular systems, typically manifesting after 20 weeks of gestation, intrapartum, or in the early postpartum period

Pathophysiologically, it is driven by systemic endothelial dysfunction, impaired cerebral autoregulation, and blood-brain barrier disruption that lead to cerebral edema and heightened neuronal excitability