Endometrial carcinoma

Endometrial carcinoma is a primary epithelial malignancy originating in the endometrium, the inner mucosal lining of the uterine corpus

Endometrial carcinoma is a primary epithelial malignancy originating in the endometrium, the inner mucosal lining of the uterine corpus It is the most common gynecologic malignancy, predominantly affecting postmenopausal individuals and typically presenting clinically with abnormal uterine bleeding or pelvic pain Contemporary classification further incorporates molecular profiles, including DNA polymerase epsilon mutations, mismatch repair deficiency, p53 abnormalities, and copy-number alteratio...

It is the most common gynecologic malignancy, predominantly affecting postmenopausal individuals and typically presenting clinically with abnormal uterine bleeding or pelvic pain Pathophysiologically, it encompasses diverse subtypes, most commonly low-grade endometrioid adenocarcinomas linked to prolonged unopposed estrogen exposure, as well as aggressive, non-hormone-driven non-endometrioid variants such as serous and clear cell carcinomas

Pathophysiologically, it encompasses diverse subtypes, most commonly low-grade endometrioid adenocarcinomas linked to prolonged unopposed estrogen exposure, as well as aggressive, non-hormone-driven non-endometrioid variants such as serous and clear cell carcinomas

Pathophysiologically, it encompasses diverse subtypes, most commonly low-grade endometrioid adenocarcinomas linked to prolonged unopposed estrogen exposure, as well as aggressive, non-hormone-driven non-endometrioid variants such as serous and clear cell carcinomas

Pathophysiologically, it encompasses diverse subtypes, most commonly low-grade endometrioid adenocarcinomas linked to prolonged unopposed estrogen exposure, as well as aggressive, non-hormone-driven non-endometrioid variants such as serous and clear cell carcinomas Contemporary classification further incorporates molecular profiles, including DNA polymerase epsilon mutations, mismatch repair deficiency, p53 abnormalities, and copy-number alterations, which dictate tumor behavior and clinical ris...