Enterobacter meningitis

Enterobacter meningitis is a severe, life-threatening bacterial infection characterized by acute inflammation of the protective leptomeninges surrounding the brain and spinal cord, caused by Gram-negative bacilli of the genus *Enterobacter* (predominantly members of the *Enterobacter cloacae* complex) Although uncommon overall, it predominantly occurs as a healthcare-associated or nosocomial central nervous system infection in neurosurgical patients, individuals with head trauma, patients with i...

Enterobacter meningitis is a severe, life-threatening bacterial infection characterized by acute inflammation of the protective leptomeninges surrounding the brain and spinal cord, caused by Gram-negative bacilli of the genus *Enterobacter* (predominantly members of the *Enterobacter cloacae* complex) Although uncommon overall, it predominantly occurs as a healthcare-associated or nosocomial central nervous system infection in neurosurgical patients, individuals with head trauma, patients with i...

Enterobacter meningitis is a severe, life-threatening bacterial infection characterized by acute inflammation of the protective leptomeninges surrounding the brain and spinal cord, caused by Gram-negative bacilli of the genus *Enterobacter* (predominantly members of the *Enterobacter cloacae* complex)

Although uncommon overall, it predominantly occurs as a healthcare-associated or nosocomial central nervous system infection in neurosurgical patients, individuals with head trauma, patients with indwelling cerebrospinal fluid devices, and immunocompromised hosts or neonates Clinical features typically include fever, altered mental status, meningismus, seizures, and marked cerebrospinal fluid pleocytosis with elevated protein and decreased glucose

Clinical features typically include fever, altered mental status, meningismus, seizures, and marked cerebrospinal fluid pleocytosis with elevated protein and decreased glucose

Management is notably challenging due to the frequent presence of inducible chromosomal AmpC beta-lactamases and acquired multidrug resistance mechanisms that limit standard antimicrobial therapy