Fever

Fever, also known as pyrexia, is a systemic physiologic response characterized by a regulated elevation of core body temperature above normal baseline levels It affects pediatric and adult populations across all organ systems and is commonly triggered by infectious pathogens, inflammatory conditions, autoimmune disorders, or neoplasms Pathophysiologically, immune cells release endogenous pyrogenic cytokines—such as interleukin-1, interleukin-6, and tumor necrosis factor—that stimulate prostaglan...

Fever, also known as pyrexia, is a systemic physiologic response characterized by a regulated elevation of core body temperature above normal baseline levels It affects pediatric and adult populations across all organ systems and is commonly triggered by infectious pathogens, inflammatory conditions, autoimmune disorders, or neoplasms

Pathophysiologically, immune cells release endogenous pyrogenic cytokines—such as interleukin-1, interleukin-6, and tumor necrosis factor—that stimulate prostaglandin E2 synthesis, resetting the hypothalamic thermoregulatory center to a higher set point

Pathophysiologically, immune cells release endogenous pyrogenic cytokines—such as interleukin-1, interleukin-6, and tumor necrosis factor—that stimulate prostaglandin E2 synthesis, resetting the hypothalamic thermoregulatory center to a higher set point

Clinically defined as a core temperature typically reaching or exceeding 38.0°C (100.4°F), it is distinguished from hyperthermia by this coordinated hypothalamic control and frequently presents alongside shivering, peripheral vasoconstriction, tachycardia, and diaphoresis

Clinically defined as a core temperature typically reaching or exceeding 38.0°C (100.4°F), it is distinguished from hyperthermia by this coordinated hypothalamic control and frequently presents alongside shivering, peripheral vasoconstriction, tachycardia, and diaphoresis