Follicular lymphoma

Follicular lymphoma is a typically indolent B-cell non-Hodgkin lymphoma arising from germinal center B lymphocytes, primarily centrocytes and centroblasts Pathophysiologically, it is defined by a nodular or follicular growth pattern and hallmark genetic alterations, most notably the t(14;18)(q32;q21) chromosomal translocation that juxtaposes the *BCL2* oncogene with the immunoglobulin heavy chain locus, leading to constitutive BCL-2 overexpression and inhibition of apoptosis

Follicular lymphoma is a typically indolent B-cell non-Hodgkin lymphoma arising from germinal center B lymphocytes, primarily centrocytes and centroblasts It predominantly affects older adults and involves the lymphatic and hematopoietic systems, commonly presenting with painless, generalized lymphadenopathy, frequent bone marrow infiltration, and splenomegaly While typically characterized by a prolonged, relapsing-and-remitting course, the disease carries an ongoing risk of histologic transform...

Follicular lymphoma is a typically indolent B-cell non-Hodgkin lymphoma arising from germinal center B lymphocytes, primarily centrocytes and centroblasts It predominantly affects older adults and involves the lymphatic and hematopoietic systems, commonly presenting with painless, generalized lymphadenopathy, frequent bone marrow infiltration, and splenomegaly While typically characterized by a prolonged, relapsing-and-remitting course, the disease carries an ongoing risk of histologic transform...

Pathophysiologically, it is defined by a nodular or follicular growth pattern and hallmark genetic alterations, most notably the t(14;18)(q32;q21) chromosomal translocation that juxtaposes the *BCL2* oncogene with the immunoglobulin heavy chain locus, leading to constitutive BCL-2 overexpression and inhibition of apoptosis